heptovir (Systemic)
Some commonly used brand names are:
In the U.S.-
Epivir
Epivir-HBV
In Canada-
3TC
Heptovir
Category
Antiviral, systemic
Description
heptovir (la-MI-vyoo-deen) is used in the treatment of the infection caused by the human immunodeficiency virus (HIV) or hepatitis B virus. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). heptovir is taken together with zidovudine (AZT) or other medications used to treat HIV.
heptovir will not cure or prevent HIV infection or AIDS however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. heptovir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease. heptovir is not a cure for the hepatitis B virus the long-term effects of the drug on the infection and the liver are unknown at this time.
heptovir is available only with your doctors prescription, in the following dosage forms:
Oral
Oral solution (U.S. and Canada)
Tablets (U.S. and Canada)
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For heptovir, the following should be considered:
Allergies-Tell your doctor if you have ever had any unusual or allergic reaction to heptovir. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy-heptovir crosses the placenta. Studies in animals have shown that heptovir causes birth defects when given in very high doses. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant. Ask your doctor to register you with the Pregnancy Registry, to monitor the effect of treatment on you and your baby.
Breast-feeding- heptovir passes into the breast milk. If your baby does not already have the AIDS virus, there is a chance that you could pass it to your baby by breast-feeding or your baby could have serious adverse reactions. Talk to your doctor first if you are thinking about breast-feeding your baby.
Children-heptovir can cause serious side effects. In one study, children with advanced AIDS were more likely than children who were less ill to develop pancreatitis (inflammation of the pancreas) and peripheral neuropathy (a problem involving the nerves). Therefore, it is especially important that you discuss with your childs doctor the good that this medicine may do as well as the risks of using it. Your child must be seen frequently and your childs progress carefully followed by the doctor while the child is taking heptovir.
Older adults-heptovir has not been studied specifically in older people. Therefore, it is not known whether it causes different side effects or problems in the elderly than it does in younger adults. Talk to your doctor first if you have liver, kidney, heart problems or other diseases. Your doctor may need to adjust your dose.
Other medicines-Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking heptovir, it is especially important that your health care professional knows if you are taking any of the following:
heptovir with zidovudine (e.g., Combivir)-Should not be used at the same time that you are taking heptovir tablets or oral solution
Zalcitabine (e.g., Hivid)-May cause problems with how heptovir or zalcitabine work when used together
Other medical problems-The presence of other medical problems may affect the use of heptovir. Make sure you tell your doctor if you have any other medical problems, especially:
Combined infection of HIV and hepatitis B-May make the condition of either of these infections worse
Diabetes mellitus (sugar diabetes)-heptovir oral solution contains sucrose
Hepatitis C or
Hepatitis delta-Caution should be used heptovir safety has not been determined in patients who have hepatitis infections
Human immunodeficiency virus-For patients with hepatitis B virus, your physician will talk to you about HIV before you begin taking heptovir. You may be tested for HIV. heptovir tablets and oral solution for hepatitis B virus contain lower amounts of the drug than the tablets and solution for HIV. If you start on the lower-dose medication and later learn that you have HIV, the higher-dose heptovir may not then be effective against the infection caused by HIV.
Inflamed pancreas or
Problems with inflamed pancreas in the past or
Other risk factors for developing an inflamed pancreas or
Nerve damage-These conditions may occur or worsen when taking heptovir
Kidney disease-Patients with kidney disease may have an increased chance of side effects
Liver disease or
Risk factors for liver disease or
Obesity (being overweight)-This medicine may make liver disease worse in patients with liver disease, obesity and other HIV medicine use.
Organ transplant-Caution should be used heptovir safety has not been determined in patients who have received an organ transplant
Proper Use of This Medicine
Take this medicine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking heptovir or zidovudine without checking with your doctor first.
Keep taking heptovir for the full time of treatment , even if you begin to feel better.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses . If you need help in planning the best times to take your medicine, check with your health care professional.
If you are using heptovir oral suspension , use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid. The heptovir oral suspension contains sucrose. Tell your doctor if you are diabetic before you start taking this medicine.
Only take medicine that your doctor has prescribed specifically for you. Do not share your medicine with others.
Dosing-The dose of heptovir will be different for different patients. Follow your doctors orders or the directions on the label . The following information includes only the average doses of heptovir. Your dose may be different if you have kidney disease. If your dose is different, do not change it unless your doctor tells you to do so:
For oral dosage forms (oral solution and tablets):
For treatment of hepatitis B infection:
Adults -100 milligrams (mg) once a day.
Children younger than 16 years of age-Use and dose must be determined by your doctor.
For treatment of HIV infection or AIDS:
Adults weighing 50 kilograms (kg) (110 pounds) or more-150 milligrams (mg) twice a day together with other HIV medications.
Adults weighing less than 50 kg (110 pounds)-2 mg per kg of body weight twice a day together with other HIV medications.
Children 3 months to 16 years of age-4 mg per kg of body weight, up to 150 mg per dose, twice a day together with other HIV medications.
Children younger than 3 months of age-Use and dose must be determined by your doctor.
Note:
Patients that require treatment for both hepatitis B and either AIDS or HIV should follow the dosing schedule for HIV or AIDS
Missed dose-If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage-To store this medicine:
Keep out of the reach of children.
Store away from heat and direct light.
Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits .
Do not take any other medicines without checking with your doctor first . To do so may increase the chance of side effects from heptovir.
If you have both HIV and hepatitis B virus (HBV) infections, deterioration of liver disease has occurred when heptovir treatment is stopped. Discuss any changes in your treatment and medicines with your doctor.
HIV may be acquired from or spread to other people through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom (“rubber”) . Only use condoms made of latex, and use them every time you have vaginal, anal, or oral sex . The use of a spermicide (such as nonoxynol-9) may also help prevent transmission of HIV if it is not irritating to the vagina, rectum, or mouth. Spermicides have been shown to kill HIV in lab tests. Do not use oil-based jelly, cold cream, baby oil, or shortening as a lubricant-these products can cause the condom to break. Lubricants without oil, such as K-Y Jelly , are recommended. Women may wish to carry their own condoms. Birth control pills and diaphragms will help protect against pregnancy, but they will not prevent someone from giving or getting the AIDS virus. If you inject drugs , get help to stop. Do not share needles or equipment with anyone . In some cities, more than half of the drug users are infected, and sharing even 1 needle or syringe can spread the virus. If you have any questions about this, check with your health care professional.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common-especially in children
Abdominal or stomach pain (severe) feeling of fullness nausea sensation or pins and needles skin rash stabbing pain tingling, burning, numbness, or pain in the hands, arms, feet, or legs unsteadiness or awkwardness vomiting
Rare
Abdominal discomfort decreased appetite diarrhea fast, shallow breathing feeling of fullness fever, chills, or sore throat general feeling of discomfort muscle pain or cramping nausea shortness of breath sleepiness unusual tiredness or weakness
Incidence not determined
Cough dark urine difficulty swallowing dizziness fast heartbeat fever hives or welts itching light-colored stools puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue redness of skin tightness in chest upper right abdominal pain wheezing yellow eyes and skin
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
More common
Canker sores difficulty in moving discouragement ear discharge ear swelling feeling sad or empty general feeling of discomfort or illness irritability loss of appetite loss of interest or pleasure nasal discharge or congestion pain in joints sores, ulcers, or white spots on lips or tongue or inside the mouth stomach pain or cramps swollen and painful spots on neck, armpit, or groin swollen joints trouble concentrating trouble sleeping unusually warm skin weight loss
Less common
Acid or sour stomach belching cough heartburn indigestion stomach discomfort or upset
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Incidence not determined
Body fat redistribution or accumulation blurred vision dry mouth flushed, dry skin fruit-like breath odor hair loss increased hunger or thirst increased urination sweating thinning of hair | 
